In October 2023, the Sinaloa Cartel looked to publicly signal that it was moving away from fentanyl trafficking amid an intensifying crackdown on its operations by U.S. and Mexican authorities. As one of two major suppliers, this would be a significant shift, but it remains unclear how genuine this announcement was. In October 2025, the Treasury Department sanctioned a slew of companies and their affiliates for allegedly supplying fentanyl precursors to a faction of Sinaloa.